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Health
Benefits of The Muscadine Grape
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Resveratrol
Resveratrol is a
substance produced by several plants that has been studied for its
health benefits, particularly in recent months.It first came to the
attention of the scientific community as the possible explanation for
the “French Paradox” – the relatively low incidences of heart disease
despite a high dietary intake of saturated fats in a study conducted in
Southern France.
Recent
studies suggest that Resveratrol has estrogenic, cardioprotective and
anticancer activities
[1] [2] [3] [4] [5] [6] [7] [8].
Resveratrol is a
naturally occurring compound present in many fruits, vegetables and
wine. It is typically associated with extracts because most fruits
(even vinifera grapes) have such small amounts of the compound, that
extract methods are the only viable solution to retrieve measurable
amounts. The
trans-and cis-resveratrol configurations are measurable in the
muscadine grape skins.
One
of the highest sources of natural Resveratrol is the skins of grapes,
particularly the thick skins of the Muscadine grapes.
The amount of
resveratrol in muscadine grapes varies by cultivar and growing
conditions. Muscadine Naturals uses a unique, chemical-free process
that maintains the high level of natural antioxidants found in the
fresh fruit. The dried fruit powders are blended for consistency. The
number of studies being conducted about resveratrol has grown at a
rapid pace since 2000. In recent months,
research has emerged on
its life-extending potential due to its apparent
ability to mimic calorie restriction (CR) in some laboratory animals.
Some of the news associated with these studies suggests large amounts
of resveratrol are needed. However, for the purpose of contributing to
antioxidant effects, 2-4mg of resveratrol have been studied as
providing an effect [2].
Another study suggests that a low amount of resveratrol is more
effective than a higher amount [9].
Other studies suggests that the presence of flavanoids in products
containing resveratrol may improve the bio-availability of the
resveratrol [10] [11].
Muscadine Naturals products contain natural flavanoids (quercetin,
myricein, kaempferol) as found in the fresh fruit, possibility
enhancing the bio-availability of the resveratrol. As research
continues, more exciting health benefits of resveratrol are sure to be
revealed.
For more studies
on Resveratrol
and other phytonutrients,
go to www.PubMed.com and
key in any of the above phytonutrients along with the word antioxidant
to find scientific studies that have been conducted all over the world.
You can also add the word “muscadine” to seek specific studies that
have been published about the muscadine grape.
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Piceatannol
Piceatannol is a
natural stilbene occurring in a number of plant species, and it has
been shown to have beneficial effects on human health. The compound can
seldom be consumed by humans, because it occurs mostly in non-food
plants, or in non-edible organs. There are only a few plants reported
to contain minute amounts of piceatannol. The scarcity of this compound
impedes researchers from continuing to study its properties and health
benefits.
Piceatannol has a
very similar structure to the renowned resveratrol and, also, similar
anti-inflammatory and antioxidant properties. However, piceatannol has
much more potent biological activity and bioavailability than
resveratrol. Like resveratrol, piceatannol
has been studied for its anti-cancer properties
and has been deemed the superior agent of the two.
It
has recently been discovered that the Muscadine grapes, along with our
Muscadine grape products, contain piceatannol.
Our
inventory of Muscadine grape skins, containing both resveratrol and
piceatannol, is the largest known supply in the world.
Our company has plans to upkeep and increase the supply of the
Muscadine grapes so that we can continue to give you the 100%
all-natural products you need for your health and happiness.
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Footnotes:
[1] Basly JP, et al.
Estrogenic/antiestrogenic and scavenging properties of (E)- and
(Z)-resveratrol. Life Sci 2000; 66(9):769-77 (PubMed).
[2] Calebrese G. Nonalcoholic
compounds in red wine: the phyotestrogn resveratrol and moderate red
wine consumption during menopause. Drugs Exp Clin Res 1999:
25(2-3):111-4 (Pub Med).
[3] Fremont L. Biological
effects of resveratrol. Life Sci 2000; 66(8):663-73 (PubMed).
[4] Jang M, et al. Cancer
chemopreventive activity of resveratrol, a natural product derived from
grapes. PMID: 8985016 (PubMed).
[5] Signorelli P, Ghidoni R.
Resveratrol as an anticancer nutrient:molecular basis, open questions
and promises. J Nutr Biochem. 2005 Aug;16(8):449-66.
[6] Hascalik
S, et al. Effects of resveratrol, raloxifene, tibolone and conjugated
equine estrogen on vaginal squamous cell maturation of ovariectomized
Rats. Gynecol Obstet Invest. 2005 Jul 11;60(4):186-191.
[7] Olas B, Wachowicz B.
Resveratrol, a phenolic antioxidant with effects on blood platelet
functions. Platelets. 2005 Aug;16(5):251-60.
[8] Fuhrman B, et al. Grape
powder polyphenols attenuate atherosclerosis development in
apolipoprotein.
[9] JG, Cq w, Hh F, Hy D, Xl X,
Ym X, By , Dj H. Effects of resveratrol on endothelial progenitor cells
and their contributions to reendothelialization in intima-injured
rates. J Cardiovasc Pharmacol 2006 May;47(5):711-21.
[10] De Santi C, Pietrabissa B,
Spisni R, Mosca F, Pacifici G:2000a. Sulphation of resveratrol, a
natural compound present in wine, and its inhibition by natural
flavonoids. Xenobiotica 30:857-866.
[11] De Santi C, Pietrabissa,
A, Spisni R, Mosca F, Pacifici G:2000b. Glucuronidation of resveratrol,
a natural product present in grape and wine, in the human liver.
Xenobiotica 30:1047-1054
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